Meta Marker Set Enrichment Analysis (Meta MSEA)
Overview
Meta MSEA
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Meta MSEA is a feature that supports meta-analysis at the pathway level. Meta-SSEA gives the user more power by combining results from independent association studies of different ethnicity, platform, or even species. Additionally, the Meta-MSEA can be used to encorporate multiple types of data (i.e. GWAS and EWAS) as long as the appropriate mapping files are supplied.
Workflow
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The Workflow of Meta-MSEA is identical to MSEA except for the addition of one step. Meta-MSEA begins by following the same steps as MSEA steps 1-5 (from association data to gene set description).
Note: Please correct for any marker dependencies (if known) using Marker Dependency Filtering.
Studies to Include
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Once all the parameters have been selected and necessary files have been uploaded/selected, the user must then select whether they would like to add an additional study to the meta-analysis, or proceed with the analysis.
IMPORTANT: There is a maximum limit of
5 separate studies to be integrated in a single Meta-MSEA run. If the user wishes to conduct Meta-MSEA with more samples, then they can use the Mergeomics R script provided in the
Downloads section.
