PharmOmics is a comprehensive drug knowledgebase comprised of genomic footprints derived from meta-analysis of microarray and RNA sequencing data relevant to drugs from tissues and cells derived from human, mouse, and rat samples in GEO, ArrayExpress, TG-GATEs and drugMatrix data repositories.

PharmOmics is a comprehensive drug knowledgebase comprised of genomic footprints derived from meta-analysis of microarray and RNA sequencing data relevant to drugs from tissues and cells derived from human, mouse, and rat samples in GEO, ArrayExpress, TG-GATEs and drugMatrix data repositories.

This tool ranks drugs based on the connectivity of drug signatures to input genes as defined by a gene network model. distance(I,D) is a network proximity measurement between drug (D) and input genes (I).

PharmOmics is a comprehensive drug knowledgebase comprised of genomic footprints derived from meta-analysis of microarray and RNA sequencing data relevant to drugs from tissues and cells derived from human, mouse, and rat samples in GEO, ArrayExpress, TG-GATEs and drugMatrix data repositories.

The Jaccard score is used as the direct overlap measurement between input genes and disease genes (unsigned for single list of genes, signed for up- and downregulated genes). The gene overlap fold enrichment, odds ratio, Fisher's exact test p-value, and within-species rank is also calculated.

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If dependency among markers are not corrected, spurious results may be generated!